Cultural dry virus vaccine against sheep pox and lumpy skin disease Description

The vaccine is applied for preventive immunization of sheep against the disease and bovine cattle in affected areas; zones and farms at risk. Pharmaceutical form - freeze-dried mass. The vaccine is a homogeneous, dry, porous mass of light yellow color, totally dissoluble in sterile 0.9% sodium chloride solution (saline solution) for 1.5 minutes.


The vaccine is used for preventive vaccination of sheep against pox and bovine cattle against lumpy skin desease in affected areas; zones and farms at risk. It is banned to vaccinate clinically diseased and/or weakened animals.

Route of administration

The virus vaccine is administered to sheep subcutaneously into the hairless skin area (fore-flank, tail patch) in compliance with the hygiene regulations (dose of 1 cm3).

Before administration the dry virus vaccine is diluted in compliance with the sanitary rules in PBS solution cooled down to 4 °C. PBS is added into vaccine bottles with a syringe (2 cm3 into a bottle containing 50 vaccine doses and 4 cm3 into a bottle containing 100 vaccine doses), then the bottles are carefully shaken till complete re-suspension.

After re-suspension the virus vaccine is pooled together with sterile PBS (48 cm3 or 96 cm3) to get 50 and 100 vaccine doses, correspondingly, and carefully shaken. Syringes and needles that have been sterilized during 20-minute boiling are used for vaccination. Disposable syringes are also permitted.

No chemicals are allowed for disinfection of syringes and needles. The skin surface at the injection site shall be treated with 70% alcohol or other disinfectants.

In case of scheduled vaccination sheep are first vaccinated at the age of 3 months. Re-vaccination is carried out every 12 months. In the affected area and on the farms within the zone at risk animals of all age groups demonstrating no signs of the disease shall be vaccinated regardless of the last vaccination date. The young animals (under 6 months) shall be vaccinated twice with a 14-day interval. In 6-7 months the young animals are revaccinated and the mature animals are vaccinated in 12 months.


Virus vaccine induces immune response in vaccinated sheep on day 5 post one vaccination and duration of the immunity is at least 12 months. The vaccine is innocuous and has no medical properties. In case of routine vaccination animals at the age of 3 months or older are inoculated for LSD prevention. The animals are revaccinated every 6 months. In infected settlement/area located in infected zone animals of all age groups without any LSD clinical signs are vaccinated irrespectively of the date of their previous vaccination. Young animals under 6 months of age are vaccinated twice at 14 day interval.

Young and adult animals are revaccinated 6 months later. The virus vaccine is aseptically administered to cattle at a dose of 1cm3 per animal subcutaneously in the middle third of the neck.

Before administration the dry vaccine is aseptically dissolved with saline solution cooled to 4°C. To do this, 2 cm3 or 4 cm3 of saline solution are injected with a syringe in a bottle containing five inoculation doses o r 10, 20, 50 inoculation doses o f the vaccine, respectively, and the bottle is thoroughly shaken till the vaccine is completely resuspended. After resuspension sterile saline solution is added to the virus vaccine as follows: 3 cm3 - to prepare 5 inoculation doses, 6 cm3 – to prepare 10 inoculation doses, 16 cm3 – to prepare 20 inoculation doses, 46 cm3 – to prepare 50 inoculation doses. Then it is thoroughly shaken.

Storage conditions

The vaccine shall be stored and transported in a dry dark place at 2 – 8 °C. The vaccine shelf life is 24 months from the production date, provided that its storage and transportation conditions are met. The virus vaccine cannot be used after the expiry date.

Sheep pox and lumpy skin disease
Strain/ serotype: 
live, dry, cultural
Filling/ dosage: 
2 and 4 cm3 flask
Measurement unit: 
one thousand doses